A major cardiac event that requires medical intervention and sometimes heart surgery, a heart attack occurs when the coronary arteries narrow so much that they cut off blood supply to the heart. This is often caused by cholesterol buildup, which can break off and block the blood vessel, depriving the heart cells of oxygen. Heart attack symptoms can be different for men and women. Heart attack symptoms in men include nausea, indigestion, heartburn, abdominal pain, shortness of breath, cold sweat, fatigue, lightheadedness, dizziness, and sensation of pressure, tightness, squeezing or aching in the chest and arm. Heart attack symptoms in women are an uncomfortable pressure, squeezing, fullness, or pain in the center of the chest, pain or discomfort in one or both arms, the back, neck, jaw, or stomach and shortness of breath with or without chest discomfort.